5-Aminoimidazole-4-carboxamide ribonucleotide — endogenous AMPK activator and established research tool.
AICAR is a research compound available through our china peptide catalog as a finished, lyophilized vial from an established Chinese manufacturer. It belongs to the Nucleoside analogue / AMPK activator
Research Areas
AMPK biology, metabolic research, exercise mimetic studies, cardiac protection, oncology research
Available Variants
| Name | Strength | Pack Size | Purity | Availability |
|---|---|---|---|---|
| AICAR | 50 mg | 10 vials | ≥98% | In Stock |
Specification Highlights
Quality & Testing
Testing method: HPLC / LC-MS ([“LC-MS”,“HPLC”,“Water Content”]) . Products are supplied against the specification shown on the applicable product page. The standard catalog purity specification is ≥98% unless otherwise stated. Product-specific specifications and quality-control information may vary by compound and batch. Available documentation: .
**Where provided, these documents reflect the manufacturer’s batch testing for this compound.
Research Areas
AMPK Activation and Metabolic Research AICAR is the most widely used pharmacological tool for AMPK activation in cell culture and in vivo research. Its intracellular conversion to ZMP — an AMP analogue — activates AMPK’s CBS regulatory domains, mimicking the high-AMP signal of cellular energy depletion. Research has used AICAR to study AMPK’s downstream effects on glucose uptake (GLUT4 translocation), fatty acid oxidation (CPT-1 regulation), and protein synthesis inhibition (mTORC1 suppression) in metabolic research contexts. Exercise Mimetic Research Rodent studies have examined AICAR as a pharmacological exercise mimetic — capable of producing skeletal muscle adaptations resembling endurance training without physical activity. Studies have documented AICAR-induced increases in oxidative enzyme expression, mitochondrial biogenesis via PGC-1α, and shift toward fatigue-resistant fiber type markers. These studies established AICAR as the reference ‘exercise in a bottle’ compound in exercise physiology research, while clarifying mechanistic differences from actual exercise adaptation. Cardiac Protection Research In cardiac ischemia-reperfusion (I/R) models, AICAR-mediated AMPK activation has been studied for cardioprotective effects including improved myocardial energetics, reduced infarct size, and preservation of mitochondrial function. AMPK’s role in activating glycolysis and inhibiting fatty acid oxidation (paradoxically, in the ischemic context) during ischemia makes AMPK a pharmacological target in cardiac research, with AICAR as a primary tool compound. ## Sourcing AICAR From China
AICAR is available through our platform as a china peptide sourced directly from an established Chinese manufacturer. Three points define how we handle it:
- Factory-direct, not trader-sourced. We confirm availability and specification with the manufacturer before the order is confirmed. There is no intermediary resale of unknown-origin vials in this catalog.
- Specification before shipment. The purity and concentration specification shown on this page is the manufacturer’s batch specification. Product-specific quality-control information travels with the order.
- Research-use discipline. Like every listing in our catalog, AICAR is supplied for laboratory research use only, under strict research-use terms.
For buyers comparing chinese peptides suppliers, the practical test is whether the seller can name the manufacturer and show the batch documentation. We work the other way around: the manufacturer and the documentation are the offer. Browse the full catalog or see how sourcing works.
Research Areas
AMPK biology, metabolic research, exercise mimetic studies, cardiac protection, oncology research
Available Variants
| Name | Strength | Pack Size | Purity | Availability |
|---|---|---|---|---|
| AICAR | 50 mg | 10 vials | ≥98% | In Stock |
Specification Highlights
Quality & Testing
Testing method: HPLC / LC-MS ([“LC-MS”,“HPLC”,“Water Content”]) . Products are supplied against the specification shown on the applicable product page. The standard catalog purity specification is ≥98% unless otherwise stated. Product-specific specifications and quality-control information may vary by compound and batch. Available documentation: .
**Where provided, these documents reflect the manufacturer’s batch testing for this compound.
Research Areas
AMPK Activation and Metabolic Research AICAR is the most widely used pharmacological tool for AMPK activation in cell culture and in vivo research. Its intracellular conversion to ZMP — an AMP analogue — activates AMPK’s CBS regulatory domains, mimicking the high-AMP signal of cellular energy depletion. Research has used AICAR to study AMPK’s downstream effects on glucose uptake (GLUT4 translocation), fatty acid oxidation (CPT-1 regulation), and protein synthesis inhibition (mTORC1 suppression) in metabolic research contexts. Exercise Mimetic Research Rodent studies have examined AICAR as a pharmacological exercise mimetic — capable of producing skeletal muscle adaptations resembling endurance training without physical activity. Studies have documented AICAR-induced increases in oxidative enzyme expression, mitochondrial biogenesis via PGC-1α, and shift toward fatigue-resistant fiber type markers. These studies established AICAR as the reference ‘exercise in a bottle’ compound in exercise physiology research, while clarifying mechanistic differences from actual exercise adaptation. Cardiac Protection Research In cardiac ischemia-reperfusion (I/R) models, AICAR-mediated AMPK activation has been studied for cardioprotective effects including improved myocardial energetics, reduced infarct size, and preservation of mitochondrial function. AMPK’s role in activating glycolysis and inhibiting fatty acid oxidation (paradoxically, in the ischemic context) during ischemia makes AMPK a pharmacological target in cardiac research, with AICAR as a primary tool compound.
Available Variants
| Name | Strength | Pack Size | Purity | Availability |
|---|---|---|---|---|
| AICAR | 50 mg | 10 vials | ≥98% | In Stock |
Specification Highlights
Quality & Testing
Testing method: HPLC / LC-MS ([“LC-MS”,“HPLC”,“Water Content”]) . Products are supplied against the specification shown on the applicable product page. The standard catalog purity specification is ≥98% unless otherwise stated. Product-specific specifications and quality-control information may vary by compound and batch. Available documentation: .
**Where provided, these documents reflect the manufacturer’s batch testing for this compound.
Research Areas
AMPK Activation and Metabolic Research AICAR is the most widely used pharmacological tool for AMPK activation in cell culture and in vivo research. Its intracellular conversion to ZMP — an AMP analogue — activates AMPK’s CBS regulatory domains, mimicking the high-AMP signal of cellular energy depletion. Research has used AICAR to study AMPK’s downstream effects on glucose uptake (GLUT4 translocation), fatty acid oxidation (CPT-1 regulation), and protein synthesis inhibition (mTORC1 suppression) in metabolic research contexts. Exercise Mimetic Research Rodent studies have examined AICAR as a pharmacological exercise mimetic — capable of producing skeletal muscle adaptations resembling endurance training without physical activity. Studies have documented AICAR-induced increases in oxidative enzyme expression, mitochondrial biogenesis via PGC-1α, and shift toward fatigue-resistant fiber type markers. These studies established AICAR as the reference ‘exercise in a bottle’ compound in exercise physiology research, while clarifying mechanistic differences from actual exercise adaptation. Cardiac Protection Research In cardiac ischemia-reperfusion (I/R) models, AICAR-mediated AMPK activation has been studied for cardioprotective effects including improved myocardial energetics, reduced infarct size, and preservation of mitochondrial function. AMPK’s role in activating glycolysis and inhibiting fatty acid oxidation (paradoxically, in the ischemic context) during ischemia makes AMPK a pharmacological target in cardiac research, with AICAR as a primary tool compound.
Compound Profile
AICAR (5-Aminoimidazole-4-carboxamide ribonucleotide), also known as Acadesine or AICA riboside, is a cell-permeable nucleoside analogue and pharmacological activator of AMP-activated protein kinase (AMPK). After cellular uptake, AICAR is phosphorylated to ZMP (AICA ribonucleotide) — a structural analogue of AMP — which allosterically activates AMPK by mimicking the energy-depleted state (high AMP/ATP ratio). AMPK is the master sensor of cellular energy status, regulating metabolic switching, mitochondrial biogenesis, glucose uptake, and fatty acid oxidation across virtually all tissues. Preclinical research using AICAR as a pharmacological AMPK activator spans metabolic research, exercise physiology, cardiac protection, and cancer biology. In rodent models, AICAR administration produces effects resembling endurance exercise: increased skeletal muscle GLUT4 expression, enhanced fatty acid oxidation, mitochondrial biogenesis (via PGC-1α), and improved insulin sensitivity. In cardiac ischemia-reperfusion models, AMPK activation by AICAR has been studied for protective effects on cardiomyocyte survival and energy restoration. In oncology research, AICAR’s AMPK-activating and adenosine kinase-inhibiting properties have been studied in cancer cell line and xenograft models. Peptides of China supplies AICAR as a lyophilized powder at 99%+ purity, verified by HPLC. Every batch is tested by the manufacturer for purity and concentration as part of routine quality control. All products are for laboratory research use only and are not for human consumption.
Profile
Research Areas
AMPK biology, metabolic research, exercise mimetic studies, cardiac protection, oncology research
Available Variants
| Name | Strength | Pack Size | Purity | Availability |
|---|---|---|---|---|
| AICAR | 50 mg | 10 vials | ≥98% | In Stock |
Specification Highlights
Quality & Testing
Testing method: HPLC / LC-MS ([“LC-MS”,“HPLC”,“Water Content”]) . Products are supplied against the specification shown on the applicable product page. The standard catalog purity specification is ≥98% unless otherwise stated. Product-specific specifications and quality-control information may vary by compound and batch. Available documentation: .
**Where provided, these documents reflect the manufacturer’s batch testing for this compound.
Research Areas
AMPK Activation and Metabolic Research AICAR is the most widely used pharmacological tool for AMPK activation in cell culture and in vivo research. Its intracellular conversion to ZMP — an AMP analogue — activates AMPK’s CBS regulatory domains, mimicking the high-AMP signal of cellular energy depletion. Research has used AICAR to study AMPK’s downstream effects on glucose uptake (GLUT4 translocation), fatty acid oxidation (CPT-1 regulation), and protein synthesis inhibition (mTORC1 suppression) in metabolic research contexts. Exercise Mimetic Research Rodent studies have examined AICAR as a pharmacological exercise mimetic — capable of producing skeletal muscle adaptations resembling endurance training without physical activity. Studies have documented AICAR-induced increases in oxidative enzyme expression, mitochondrial biogenesis via PGC-1α, and shift toward fatigue-resistant fiber type markers. These studies established AICAR as the reference ‘exercise in a bottle’ compound in exercise physiology research, while clarifying mechanistic differences from actual exercise adaptation. Cardiac Protection Research In cardiac ischemia-reperfusion (I/R) models, AICAR-mediated AMPK activation has been studied for cardioprotective effects including improved myocardial energetics, reduced infarct size, and preservation of mitochondrial function. AMPK’s role in activating glycolysis and inhibiting fatty acid oxidation (paradoxically, in the ischemic context) during ischemia makes AMPK a pharmacological target in cardiac research, with AICAR as a primary tool compound.